HSP60: Alternate Names

IHC staining of human colon cancer, using Anti-Hsp60 (clone: LK2)
The progressive expansion of the heat shock (stress) protein field has led to inconsistencies and a lack of clarity in the nomenclature for these families of molecules. As a consequence, Kampinga and colleagues have proposed new guidelines to encourage the use of consistent and clear terminology 60. Members of the 60 kDa family of heat shock proteins (HSP60s) are also designated as chaperonins (CPNs) 1. Table 2 lists various pro- and eukaryotic HSP60s together with their alternate names. Eubacteria express up to seven Hsp60 homologs, referred to as GroEL (high-temperature protein G). Amongst the eukaryotic species, HspD1 (UniProt ID #P10809); also known as mitochondrial Hsp60 (mtHsp60), 60 kDa chaperonin (Cpn60), mitochondrial matrix protein P1, P60 lymphocyte protein, is among the most prominent HSP60 found in stressed and non-stressed cells. The Hsp60 homolog in the chloroplasts of higher plants is the ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) subunit-binding protein (RBP) required for the assembly of the enzyme complex 29. In the cytosol of eukaryotes and Archaea, HSP60s are referred to as chaperone containing T-complex polypeptide 1 (CCT) proteins forming the hetero-oligomeric TCP-1 ring complex (TRiC). CCTs of Archaea are strongly induced by heat shock comprising up to 40% of total cellular protein in the thermophilic Archaeon Sulfolobus shibatae after heat exposure 61. Based on these findings, the chaperonin complex in Archaea is referred to as the thermosome or thermophilic factor 55 (TF55).